New research suggests that people who stop using blockbuster weight-loss injections like Wegovy and Mounjaro may regain shed pounds much more quickly than those who stop traditional lifestyle programs.
Published data in a leading medical journal demonstrates that while overweight individuals can lose a large proportion of their total mass while undergoing treatment, the weight returns at an estimated rate of 0.8 kg per month upon discontinuation.
"Individuals purchasing these medications should be aware of the danger of quick rebound weight gain when the therapy ends," warns lead investigator Dr. Susan Jebb.
That rate of recovery suggests a return to original weight in about 18 months.
Comparing Treatments
The analysis, which examined 37 of studies involving over 9,000 of participants, compared the results of these new drugs with older methods.
Researchers point out that individuals who lose weight through lifestyle changes alone typically have a less rapid creep back—around 100 grams monthly—after stopping.
The Reason for the Rapid Regain
Nutrition scientists believe the way of the injections accounts for the amplified regain.
The injections imitate a natural hormone called glucagon-like peptide-1, which controls hunger.
"Sustained high doses of GLP-1 levels several times higher than the body's typical production may cause the body to generate a reduced amount of its endogenous GLP-1, and could reduce responsiveness to its effects," said Dr. Adam Collins, a dietetics specialist.
"Stopping of this hormone supplement results in hunger is uncontrolled, making overeating a significant risk."
A Lifelong Issue?
The NHS recommend the injections for people with obesity-related medical conditions, accompanied by prescribed diet and exercise modifications.
Professionals say that, considering the high risk of relapse, the therapy might need to be long-term.
This view is supported by drug manufacturers, who say that the findings "underscore the persistent nature of excess weight," similar to managing diseases like hypertension.
Patient Testimonies
Users who have stopped the jabs describe a intense return of appetite.
"I experienced something activating and you become ravenous," recalled an individual.
The struggle is compounded if individuals have not established lasting lifestyle or habit modifications during therapy.
Significant Use
Figures indicate that millions of people in the UK have used these injections in the last 12 months, with interest continuing to grow.
- Adoption is higher among females than males.
- The middle-aged demographic shows the highest usage rates.
- A large proportion access the medications through private prescriptions rather than public health services.
In conclusion, experts emphasize that while these medications are powerful tools for shedding pounds, they are not a standalone solution and lasting health benefits hinges on integrated behavioural management.
